陈典克主治医师 讲师

研究方向为结直肠肿瘤发生发展分子机制研究，主要研究内容为遗传多态性与肠癌易感性。开展MAPK信号通路关键基因多态性与结直肠肿瘤发病相关的课题，研究发现c-Jun、NfkBIa、MKK4、MEK5等多个基因多态性与肠癌易感性相关。近年来围绕非编码RNA在结直肠肿瘤发生发展中的作用开展相关研究。此外，在表观遗传、肠癌侵袭转移方面也进行深入研究。研究结果在Carcinogenesis，InternationalJournalofoncology,PloSOne，InternationalJournalofClinicalPractice，ProteomicsClinicalApplications，DNAandCellBiology，BritishJournalofCancer，JournalofGastrointestinalSurgery，HumanPathology等杂志上发表目前为止，作为主要作者发表文章多篇，其中SCI文章14篇，其中通讯/第一作者4篇。曾获中山大学优秀研究生导师逸仙创新人才培养计划、教育部博士研究生学术新人奖资助，主持承担国家自然科学基金青年项目、广东省自然科学基金面上项目、中山大学青年教师培育项目3项，参与多项国家自然科学基金、教育部博士点基金、广东省自然科学基金等项目研究。教育经历：2007/9-2012/6，中山大学，医学博士2002/9-2007/7，中山大学，医学学士工作经历：2016/01-至今，中山大学附属第六医院，主治医师2012/07-2015/12，中山大学附属第六医院，医师2012/07-至今，中山大学，附属第六医院，讲师近年发表相关论文:1.第一作者论文(1)ChenD#,SongS,LuJ,LuoY,YangZ,HuangQ,FuX,FanX,WeiY,WangJ*,WangL*.Functionalvariantsof-1318TGand-673CTinc-Junpromoterregionassociatedwithincreasedcolorectalcancerriskbyelevatingpromoteractivity.Carcinogenesis.2011;32:1043-9(2)SongS#,ChenD#,LuJ,LiaoJ,LuoY,YangZ,FuX,FanX,WeiY,YangL,WangL*,WangJ*.NFkappaB1andNFkappaBIAPolymorphismsAreAssociatedwithIncreasedRiskforSporadicColorectalCancerinaSouthernChinesePopulation.PLoSOne2011;6:e217262.通讯作者论文(1)ZixuYuan#,XihuYu,BeibeiNi,DaiciChen,ZihuanYang,JintuanHuang,JianpingWang,DiankeChen*,LeiWang*.OverexpressionofnovellongnoncodingRNA-CTD903inhibitscolorectalcancerinvasionandmigrationbyrepressingWnt/β-cateninsignalingandpredictsfavorableprognosis.Internationaljournalofoncology.2016;48(6):2675-85(2)NiB#,YuX,GuoX,FanX,YangZ,WuP,YuanZ,DengY,WangJ,ChenD*，WangL*.Increasedurothelialcancerassociated1isassociatedwithtumorproliferationandmetastasisandpredictspoorprognosisincolorectalcancer.Internationaljournalofoncology.2015;47:1329-383.既非第一作者又非通讯作者论文(1)DengY*,WangL,TanS,KimGP,DouR,ChenD,CaiY,FuX,WangL,ZhuJ,WangJ*.KRASasapredictorofpoorprognosisandbenefitfrompostoperativeFOLFOXchemotherapyinpatientswithstageIIandIIIcolorectalcancer.MolecularOncology.2015;9(7):1341-7(2)SongS#,ChenD,MaT,LuoY,YangZ,WangD,FanX,QinQ,NiB,GuoX,XianZ,LanP,CaoX,LiM,WangJ*,WangL*.Molecularmechanismofacuteradiationenteritisrevealedusingproteomicsandbiologicalsignalingnetworkanalysisinrats.DigestiveDiseasesandSciences.2014,59(11):2704-13.(3)HuangQ#,ChenD,SongS,FuX,WeiY,LuJ,WangL*,WangJ*.Ageneticvariationofthep38βpromoterregioniscorrelatedwithanincreasedriskofsporadiccolorectalcancer.OncologyLetters.2013Jul;6(1):3-8(4)FanXJ#,WanXB#,YangZL#,FuXH,HuangY,ChenDK,SongSX,LiuQ,XiaoHY,WangL*,WangJP*SnailpromoteslymphnodemetastasisandTwistenhancestumordepositformationthroughepithelialmesenchymaltransitionincolorectalcancer.HumanPathology2013；44(2):173-80(5)DiaoD#,WangL,ZhangJ,ChenD,LiuH,WeiY,Luj,PengJ*,WangJ*.Mitogen/ExtracellularSignal-RegulatedKinaseKinase-5PromoterRegionPolymorphismsAffecttheRiskofSporadicColorectalCancerinaSouthernChinesePopulation.DNAandCellBiology.2012;31(3):342-9(6)FanXJ#,WanXB#,HuangY#,CaiHM,FuXH,YangZL,ChenDK,SongSX,WuPH,LiuQ,WangL*,WangJP*.Epithelial-mesenchymaltransitionbiomarkersandsupportvectormachineguidedmodelinpreoperativelypredictingregionallymphnodemetastasisforrectalcancer.BritishJournalofCancer.2012;106(11):1735-41(7)LuoY#,ChenD,SongS,WangL*,WangJ*.Aberrantmethylationofgenesinstoolsamplesasdiagnosticbiomarkersforcolorectalcanceroradenomas:Ameta-analysis.InternationalJournalofClinicalPractice.2011;65:1313-20(8)LiuB#,ChenD,YangL,LiY,LingX,LiuL,JiW,WeiY,WangJ,WeiQ,WangL*,LuJ*.Afunctionalvariant(-1304TG)intheMKK4promotercontributestoadecreasedriskoflungcancerbyincreasingthepromoteractivity.Carcinogenesis.2010;31:1405-11(9)LuoY#,WangL#,ChenC#,ChenD,HuangM,HuangY,PengJ,LanP,CuiJ,CaiS,WangJ*.Simultaneousliverandcolorectalresectionsaresafeforsynchronouscolorectallivermetastases.JournalofGastrointestinalSurgery.2010;14:1974-80.(10)LuoYX#,CuiJ,WangL,ChenDK,PengJS,LanP,HuangMJ,HuangYH,CaiSR,HuKH,LiMT,WangJP*.Identificationofcancer-associatedproteinsbyproteomicsanddownregulationofbeta-tropomyosinexpressionincolorectaladenomaandcancer.ProteomicsClinicalApplications.2009;3:1397-406.4.中文文章(1)王磊,陈典克,汪建平.结直肠癌分子分型研究发展方向.中华实验外科杂志.2012,29(2):176-7(2)王磊,陈典克,汪建平.重视结直肠癌的预防与筛查.中华实验外科杂志.2011,28(1):9-11(3)赵日升,王辉,王磊,黄美近,陈典克,汪建平.术前腔内支架与急诊手术治疗左半结肠和直肠癌肠梗阻的安全性与有效性Meta分析.中华胃肠外科杂志,2012,15(7):697-701(4)鲜振宇,王磊,任东林,陈典克,宋顺心,黄清华,汪建平,刁德昌.ERK5基因-322G/T多态性与散发性结直肠癌易感性的关系.中国病理生理杂志.2011,27(4):699-704(5)王磊,杨祖立,陈典克,宋顺心,兰平,汪建平.MKK4腺病毒载体的构建及其对胰腺癌细胞增生和浸润能力的影响.中华实验外科杂志.2010,27(9):1283-1285(6)傅新晖,邓艳红,范新娟,骆衍新,陈典克，王磊,兰平,刘焕亮,汪建平.利用高分辨率熔解曲线分析法检测结直肠癌中KRAS基因突变.中华普通外科学文献(电子版).2009,3(5):376-378.